The Japanese clinical guidelines 2022 for myasthenia gravis and Lambert–Eaton myasthenic syndrome
نویسندگان
چکیده
The revised Japanese clinical guidelines for myasthenia gravis (MG) and Lambert–Eaton myasthenic syndrome (LEMS) were published in 2022. notable points these (GLs) are as follows: (i) the first GLs to include a description of LEMS; (ii) diagnostic criteria MG lessen incidence false negative patients; (iii) is divided into six subtypes; (iv) high-dose oral steroid regimen with escalation de-escalation schedule not recommended by GLs; (v) promote early fast-acting treatment strategy initially proposed previous (vi) refractory defined; (vii) use molecular targeted drugs included; (viii) LEMS proposed; (ix) algorithms both presented. These new expected improve patients' quality life will serve bridge present era eras.
منابع مشابه
Difference in distribution of muscle weakness between myasthenia gravis and the Lambert-Eaton myasthenic syndrome.
BACKGROUND Myasthenia gravis and the Lambert-Eaton myasthenic syndrome (LEMS) may have a similar distribution of muscle weakness. Deciding on a diagnosis of myasthenia gravis or LEMS on clinical grounds may therefore be difficult. OBJECTIVE To compare the localisation of initial muscle weakness and the distribution of weakness at the time of maximum severity in patients with myasthenia gravis...
متن کاملMyasthenia gravis and Schmidt syndrome.
We describe a 47 year old woman with a 30-year history of generalized myasthenia gravis whose condition had been stable and well controlled on a combination of pyridostigmine and ephedrine until she presented. At this time she gave a 2 month history of weakness, nausea, vomiting and more recently intermittent confusion. Investigations confirmed both primary hypothyroidism and primary adrenal fa...
متن کاملIgG fc N-glycosylation changes in Lambert-Eaton myasthenic syndrome and myasthenia gravis.
N-glycosylation of the immunoglobulin Fc moiety influences its biological activity by, for example, modulating the interaction with Fc receptors. Changes in IgG glycosylation have been found to be associated with various inflammatory diseases. Here we evaluated for the first time IgG Fc N-glycosylation changes in well-defined antibody-mediated autoimmune diseases, that is, the neurological diso...
متن کاملChina guidelines for the diagnosis and treatment of myasthenia gravis
Received: 03-12-2015; Accepted: 05-01-2016 Myasthenia gravis (MG) is neuromuscular disorder induced neurotransmission defects at the neuromuscular junctions. MG is an autoimmune disease in which the autologous immune system, including the corresponding antibodies, immune cells and complement systems, attacks the cholinergic receptor (AChRs) of the postsynaptic membrane, resulting in weakness of...
متن کاملA Patient with Coexisting Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome
BACKGROUND The coexistence of myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) is very rare and remains controversial. CASE REPORT A 48-year-old woman initially presented with noticeable right ptosis and intermittent diplopia. She then developed fluctuating proximal limb weakness and difficulty in swallowing. The serum titer of anti-acetylcholine-receptor antibody was eleva...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical and Experimental Neuroimmunology
سال: 2023
ISSN: ['1759-1961']
DOI: https://doi.org/10.1111/cen3.12739